Clinical Studies

Green-lipped mussel extract and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles

The aim of this study was to investigate how changes in the gastrointestinal tract (GIT) microbiota profile may influence nutraceutical efficacy in osteoarthritis (OA) and allow the formulation of a hypothesis that explains in part the inconsistent and contentious findings from OA clinical studies with green-lipped mussel (GLM) and glucosamine.

Green-lipped mussel (Perna canaliculus) extract efficacy in knee osteoarthritis and improvement in gastrointestinal dysfunction: a pilot study

The aim of this study was to investigate the efficacy of a high-dose New Zealand green-lipped mussel (GLM) extract in patients diagnosed with Osteoarthritis of the knee and assess GLM impact on Gastrointestinal function. Results demonstrated that green-lipped mussel significantly improved knee joint pain, stiffness and mobility.

Nutritional Content and Therapeutic Evaluation of Green-lipped Mussel Extract

Perna canaliculus (Green-Lipped Mussel) is found only in New Zealand waters and is cultivated and manufactured for both the food and nutraceutical industry world-wide. P. canaliculus has traditionally been used as a therapeutic to treat various arthralgias in both humans and animals; however, clinical research reports provide conflicting results.